|Statement||E. Morton Bradbury, Norman Maclean, Harry R. Matthews.|
|Contributions||Maclean, Norman, 1932-, Matthews, Harry Roy, 1942-|
|LC Classifications||QH599 .B7|
|The Physical Object|
|Pagination||xvii, 281 p. :|
|Number of Pages||281|
|LC Control Number||81003321|
In eukaryotes, DNA is always associated with proteins, called histones (most are octamers, i.e., complexes of eight proteins) to form the 'chromatin fibre' that makes up our chromosomes. The basic unit of chromatin is the nucleosome core particle (figure 2 (a)). Chromosomes and chromatin are a uniquely eukaryotic association of DNA with more or less protein. Bacterial DNA (and prokaryotic DNA generally) is relatively ‘naked’ – not visibly associated with protein. The electron micrograph of an interphase cell (below) reveals that the chromatin can itself exist in various states of condensation. It then describes the histone-DNA interactions and the subunits isolated either from chromatin or from nuclei. It also explains the post-synthetic modifications of histone structure. Furthermore, the book talks about the chemistry and function of nuclear nonhistone proteins, low molecular weight nuclear RNA, and polytene chromosome structure. His current interests include the biophysics of DNA, chromatin and chromosomes, but also cell motility, active matter and liquid crystal physics. Davide has coauthored about articles on these and related topics in peer-reviewed journals, and he is author of a couple of popular physics articles in Physics World.
An unreplicated chromosomes can undergo replication, to produce a replicated chromosome that has two sister chromatids, which are physically connected to each other at the centromere and remain joined until cell e a pair of sister chromatids is produced by the replication of a single DNA molecule, their sequences are essentially identical (same . "This book would be perfect for anyone beginning to work on chromosomes who wants to get a rapid overview of the field. I also recommend this book to established chromosome biologists, simply because it is edifying to see the range of topics covered in this book knitted together so skillfully. Eucaryotic DNA Is Packaged into a Set of Chromosomes. In eucaryotes, the DNA in the nucleus is divided between a set of different chromosomes. For example, the human genome—approximately × 10 9 nucleotides—is distributed over 24 different by: Additional Physical Format: Online version: Bradbury, E. Morton. DNA, chromatin and chromosomes. New York: Wiley, (OCoLC) Document Type.
Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. The Cell Nucleus: Chromatin, Part A is a collection of papers that deals with the fundamental research involving cellular responses to environmental stimuli and stress. One paper describes the ultra-structural organization of chromosomes and certain eukaryotic chromatin fractions as seen by a scanning electron microscope. ISBN: OCLC Number: Description: xvii, pages: illustrations ; 24 cm: Responsibility: E. Morton. Integrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes .